Document Type
Poster
Publication Title
Northrop Grumman Engineering & Science Student Design Showcase
Abstract
Alzheimer’s Disease involves the self-assembly and aggregation of tau and Aꞵ proteins, leading to the formation of amyloid fiber deposits in the brain. The development of these protein aggregates results in neuron death. Amyloid fibers link to form a fibrous network that stabilizes the surrounding solution, forming a hydrogel. Hydrogels can be used as a model for neurotoxicity. Due to high viscosity, hydrogels restrict the flow of molecules; the presence of gels within and around neurons could thus restrict the flow of essential molecules necessary for neuron health.
Advisor
Shaohua Xu
Publication Date
4-25-2025
Recommended Citation
Wheeler, Aubrey; Orth, Connor; Crews, Rachael; and Xu, Shaohua, "Brazil Nut Effect on Protein Amyloid Hydrogel Formation" (2025). Biomedical Engineering and Sciences Student Publications. 20.
https://repository.fit.edu/bces_student/20