Northrop Grumman Engineering & Science Student Design Showcase
For research of cancer and other diseases,it has become increasingly more important to have accurate 3D culture models that more closely mimic in vivo tissues and the surrounding extracellular matrix (ECM). The current and past two-dimensional (2D) cell culture models fail to provide a complex ECM environment that is necessary to understand the cellular reactions that occur in response to different drugs and therapeutics, while animal models are time consuming, expensive, and constantly fail to reflect human tumor biology. 3D bioprinting has recently emerged as a viable solution to this problem offering increased efficiency and reproducibility, however, these options are often too expensive ($10,000-200,000) for the average researcher to utilize. Manually producing these 3D culture models has proven to be a difficult and expensive task for many researchers, often resulting in high scaffold-to-scaffold variability.
Kunal Mitra, David Beavers
Bocinsky, John; Mason, Eric; Weaver, Nevada; and Wood, Kristin, "Cell Ray 3D Bioprinter" (2016). Biomedical Engineering and Sciences Student Publications. 6.