Date of Award

5-2025

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Mathematics and Systems Engineering

First Advisor

Venkat Keshav Chivukula, Ph.D.

Second Advisor

Luis Daniel Otero, Ph.D.

Third Advisor

J. Travis Hunsucker, Ph.D.

Fourth Advisor

Gnana Bhaskar Tenali, Ph.D.

Abstract

Simulation modeling has become an essential tool for optimizing complex systems, especially in healthcare, where it plays a significant role in advancing decision-making and improving patient outcomes. One critical area benefiting from simulation is the study of cardiovascular diseases, where fluid dynamics modeling aids in understanding hemodynamics, the flow of blood through the body. Accurate hemodynamic simulations help personalize treatment plans, minimize risks, and reduce the need for invasive procedures.

This thesis explores the intersection of systems engineering and biomedical fluid dynamics modeling, aiming to bridge the gap between simulation and clinical practice. The research introduces a framework for enhanced fluid visualization that can model a variety of cardiovascular geometries, which will be implemented in the Multiscale Cardiovascular Fluids Lab at the Florida Institute of Technology. The research further presents the development of DripDrop, a hemodynamic simulation tool, which integrates systems engineering principles to enhance the accuracy and accessibility of fluid dynamics modeling. While DripDrop is in its early stages, it addresses several usability challenges, and ongoing development aims to improve its accuracy and expand its clinical applications. This work provides a foundation for using fluid dynamics modeling as a more practical and accessible tool for research and clinical decision-making in cardiovascular care.

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Available for download on Tuesday, November 11, 2025

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