In Vitro Activities of 2,2'-Bipyridyl Analogs against Mycobacterium leprae

Authors

Arvind Madhav Dhople
Maria Antonia Ibáñez
Anita A. Dhople

Document Type

Article

Publication Title

Antimicrobial Agents and Chemotherapy

Abstract

In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 μg/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 μg/ml), VUF-8514 was equally bactericidal against M. leprae.

Last Page

2909

DOI

2909

Publication Date

12-1994

Recommended Citation

Dhople, A.M., Ibanez, M.A., Dhople, A.A. In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae (1994) Antimicrobial Agents and Chemotherapy, 38 (12), pp. 2908-2909.