Antimicrobial Agents and Chemotherapy
In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 μg/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 μg/ml), VUF-8514 was equally bactericidal against M. leprae.
Dhople, A.M., Ibanez, M.A., Dhople, A.A. In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae (1994) Antimicrobial Agents and Chemotherapy, 38 (12), pp. 2908-2909.