Chemistry and Chemical Engineering Student Publications

Document Type

Poster

Publication Title

Northrop Grumman Engineering & Science Student Design Showcase

Abstract

Photocaging involves inhibiting a molecule’s function with a photolabile protecting group (PPG), allowing for precise spatiotemporal control and release of the molecule in vivo. Photocages which respond to UV light upon single photon irradiation have limited use in vivo due to cytotoxicity. Thiocoumarin is a promising photocage which absorbs in the visible light region and can cage multiple essential neurotransmitters, such as GABA and glutamate. In addition, thiocoumarin can be easily tracked through live cells due to its persistent fluorescence throughout the caging process. In this project, GABA was utilized to explore the properties of thiocoumarin as a light-triggered photocage.

Advisor

Nasri Nesnas

Publication Date

4-24-2026

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Included in

Chemistry Commons

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