Date of Award

5-2017

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Biomedical and Chemical Engineering and Sciences

First Advisor

D. Andrew Knight

Second Advisor

Nasri Nesnas

Third Advisor

Mary L. Sohn

Fourth Advisor

Michael S. Grace

Abstract

Vanadium compounds are known to play many roles in both biology and industry, and the biochemical activity of these compounds has led to their increased importance in both biological and medical research. In the present work, some new substituents for hydrazinecarbodithioate Schiff base ligands and their dioxo vanadium(V) complexes were synthesized and characterized by ¹H NMR, ¹³C NMR, DART mass, FT-IR, UV-vis, fluorescence spectrometer, and single X-ray diffraction analysis for complex K[VO₂{(S-benzyl-3-(2-hydroxy-5-nitrophenyl) methylene dithiocarbazate)}] (212). Dioxovanadium(V) complexes K[VO₂{(S-methyl-3-(2-hydroxy-5-nitrophenyl)methylenedithiocarbazate)}] (211) and 212 have been tested for antibacterial activity against Burkholderia pseudomallei and Burkholderia mallei strains. Ceftazidime was used as a reference in this study. Complex 212.has been shown to have higher antibacterial activity compared to complex 211. In some strains the minimum inhibitory concentration (MIC) values of complex 212 are only 2-fold higher than Ceftazidime and the antibacterial activity of this complex against B. pseudo is stronger than it is against B. mallei. Based on these results, we synthesized some hydrazine carbodi- thioate Schiff base ligands which have derivatives of the benzyl group to test their antibacterial ability against B. pseudomallei and B. mallei strains. The ligands 203, 204, and 205 show a stronger intensity of fluorescence in comparison with their complexes 213, 214, and 215, respectively. The fluorescent properties of vanadium complexes allow them to be used as cellular imaging agents in living cells.

Comments

Copyright held by author

Download

Included in

Chemistry Commons

Share

COinS